U.S. road system question

[robkelk]

Is there a road in the USA - a ribbon of highway that can be driven without taking an on-ramp or off-ramp in the middle of the trip, not necessarily a single Interstate - equivalent to Canada's Trans-Canada Highway?

The defining characteristic of the Trans-Canada Highway is that it stretches from the Atlantic Ocean to the Pacific Ocean. It has different names or numbers in different provinces, but it's identified as the Trans-Canada Highway along its entire route. (While it exists in all ten provinces, it doesn't extend to the territories, and the section in PEI is as connected as are the Interstates in Alaska. Thus, it doesn't matter whether the road that I'm wondering exists does or doesn't pass through all 48 contiguous states.)

IIRC, "Route 66" only went as far east as Chicago, so it isn't long enough...